Identification of potassium and chloride channels in eccrine sweat glands

Secretion of eccrine sweat glands during exercise.

The Ultrastructure and Histophysiology of Human Eccrine Sweat Glands

The electron microscopy of human eccrine sweat glands has been studied before and after stimulation by pilocarpine iontophoresis. The identity of the dark and clear cells in the secretory segment as defined by Montagna et al. (23) was determined by studying serial sections, thin for electron microscopy and thick for light microscopy. Cells with numerous apical secretory vacuoles are termed muco...

Metabolic studies of isolated human eccrine sweat glands.

This paper describes a method for isolating and studying the metabolism of human eccrine sweat glands. (a) Electron microscopy of glands which had been isolated and then incubated for an hour revealed no apparent alteration in morphology. (b) Known variation in gland size (male > female > children) was reflected in the relative rates of lactate production. (c) Lactate production was approximate...

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis and hyperthermia at high ambient temperatures. Here we have shown that CRAC channel-deficient patients and...

Electron microscopic study on human eccrine sweat glands.

Electron microscope observations on eccrine sweat glands have been carried out by many workers, namely on human eccrine swear glands by HIBBS (1958), IIJIMA (1959), CHRALES (1960), KUROSUMI et al. (1960), and MUNGER (1961) and on those of animals by KITAMURA (1958), MUNGER et al. (1961), ELLIS et al. (1961), MATSUZAWA et al. (1963), KUROSUMI et al. (1964) and TERZAKIS (1964). Already by means o...